Eradication of Burkholderia Species in Children with Cystic Fibrosis

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Background:

“As with P. aeruginosa, some isolates of Bcc, particularly B. multivorans, can be successfully eradicated with early aggressive
antibiotic therapy before chronic infection becomes established (Etherington et al, 2003). We therefore treat all patients with new
growths of Bcc with a regimen of three intravenous antibiotics (e.g. tobramycin plus meropenem plus ceftazidime) for two weeks
followed by three consecutive months of nebulised TOBI®. There is also anecdotal evidence that eradication can be enhanced by
giving aerosolised amiloride and tobramycin in combination (Middleton et al, 2005), a new strategy that we will pursue on a caseby-case basis”
The Leeds Method of Management. April, 2008. Burkholderia cepacia complex

“We attempt to eradicate first isolation with IV antibiotics, and choice will depend on sensitivities, and may include meropenem,
temocillin.” Brompton Paediatric CF Management Guideline 2017

EVALUATION

ANNUAL AUDIT OF:

  • BURKHOLDERIA ACQUISITION RATE
  • BURKHOLDERIA ERADICATION RATE
References

Horsley A, Webb K, Bright-Thomas R, Govan J, Jones A. Can Early Burkholderia Cepacia Complex Infection In Cystic Fibrosis Be Eradicated With Antibiotic Therapy?. Front Cell Infect Microbiol. 2011;1:18. Published 2011
Leeds Paediatric CF Unit: The Leeds Method Of Management. April, 2008. Burkholderia Cepacia Complex
Brompton CF Management Guidelines 2017
Cf Trust 2009 “Antibiotic Treatment “
West Of Scotland Adult Cf Unit 2015- Burkholderia Eradication Protocol 2018

Editorial Information

Last reviewed: 01 November 2019

Next review: 01 October 2019

Author(s): DR JANE WILKINSON; DR CHRISTINE PETERS; DR ROSIE HAGUE; MR STEVE BOWHAY

Version: 1

Approved By: Paediatric Drugs & Therapeutics Committee