Oral antibiotics for children with Cystic Fibrosis

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Background

Oral antibiotics may be used in CF for:

ORAL ANTIBIOTICS - PROPHYLAXIS – STAPHYLOCOCCUS AUREUS COLONISATION

ANTIBIOTIC

DOSE

NOTES

FLUCLOXACILLIN

From Birth
<5kg 62.5 mg bd 
5- 10kg 125 mg bd 
10-20 kg 250 mg bd
20 - 40kg 500mg bd
> 40kg 1g bd

 

 

 

Consider stopping at age 6 yrs if S aureus not cultured within last 12 months. 

AZITHROMYCIN 2

PENICILLIN
ALLERGY

 

<15kg: 10mg/kg  MON/WED/FRI

15-40 kg: 250mg MON/WED/FRI

>40kg: 500mg MON/WED/FRI

ORAL ANTIBIOTICS - ADDITIONAL (“SECOND-LINE”) ORAL ANTIBIOTIC TO TREAT NEW COUGH

Notes on Viral Colds

In keeping with current advice 1, if patients have coryzal symptoms only without cough, no additional antibiotics are required

If cough develops, patients should start their additional “second-line” antibiotics.

References
  1. Doring G et al. Treatment of lung infection in patients with cystic fibrosis: current and future strategies. J Cyst Fibros. 2012 Dec;11(6):461-79. doi: 10.1016/j.jcf.2012.10.004. Epub 2012 Nov 6
  2. Chmiel JF, Konstan MW, Elborn JS. Antibiotic and anti-inflammatory therapies for cystic fibrosis. Cold Spring Harb Perspect Med. ;3(10):a009779. Published . doi:10.1101/cshperspect.a009779 2013
  3. CF Trust Antibiotic Treatment for Cystic Fibrosis  2009
  4. Brompton Paediatric CF Guidelines 2017  [* Revised prophylactic Azithromycin dose 2019 for inclusion in 2020 version]
  5. Scottish Paediatric Cystic Fibrosis Managed Clinical Network Prescribing Guidelines 2015

 

Editorial Information

Last reviewed: 01 November 2019

Next review: 01 October 2021

Author(s): DR JANE WILKINSON; DR CHRISTINE PETERS; DR ROSIE HAGUE; MR STEVE BOWHAY

Version: 1

Approved By: Paediatric Drugs & Therapeutics Committee