Continuous cardiorespiratory monitoring
Including:
- ECG
- Blood pressure
- Oxygen saturations
To provide a guideline for the use of Isoprenaline Hydrochloride in paediatric complete heart block.
This guideline is intended for all healthcare professionals involved in the care of paediatric patients with complete heart block who require treatment with Isoprenaline Hydrochloride.
For neonatal guidance refer to the West of Scotland NEONATAL Parenteral Drug Monographs
Background:
Preparations:
Isoprenaline Hydrochloride Injection 1mg/5ml
Dose:
IV Infusion Dose for Complete Heart Block2:
IV Infusion: 0.1-1micrograms/Kg/minute
Infusion rate to be titrated according to clinical response. Dose may be increased every 2-3 minutes until appropriate response obtained as directed by Consultant Cardiologist.
Route of administration3:
Continuous intravenous infusion, preferably via a central line.
Isoprenaline has a low PH and may cause venous irritation and tissue damage in cases of extravasation.
If a central line is not available, administer via a large peripheral vein.
Dilution3:
Diluent : Glucose 5% (preferred) or Nacl 0.9%
Line |
Maximum Concentration |
PERIPHERAL |
20micrograms/ml |
CENTRAL |
60micrograms/ml |
Peripheral line: Add 1mg (5mls) Isoprenaline hydrochloride to 45mls of diluent to make a final concentration of 1mg/50ml (20micrograms/ml)
If requiring doses greater than 25mls/hour:
Prepare an infusion of 10mg Isoprenaline hydrochloride in 500mls diluent
Central line: Add 3mg (15ml) Isoprenaline to 35mls of diluent to make a final concentration of 3mg/50ml (60micrograms/ml)
If requiring doses greater than 25mls/hour:
Prepare an infusion of 30mg (150mls) Isoprenaline hydrochloride in 350mls diluent
To calculate infusion rate:
Continuous cardiorespiratory monitoring
Including: