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  6. Hypospadias Repair, Post Operative Pharmaceutical Management, Paediatrics (232)

Hypospadias Repair, Post Operative Pharmaceutical Management, Paediatrics (232)

Warning

Objectives

To provide a consistent and safe approach to the pharmaceutical post-operative management of patients following hypospadias repair.

Scope

Applies to all patients following hypospadias repair within The Royal Hospital for Children Glasgow.

Audience

Roles and Responsibilities

All health care professionals providing medicines for the postoperative management of patients following hypospadias repair.

1. Repair with stent e.g TIP/Snodgrass or Staged Repair Post- operative Pharmaceutical Care Pathway

Duration of treatment is for the duration the stent remains in place. This is usually 7 days although may be ten days depending on the day surgery falls upon.

If stent is suprapubic duration of treatment may be extended as per surgical consultant’s instruction.

Use of prophylactic antibiotic post-surgery is no longer used for all patients in repair with stents but may be considered on consultant advice.

1.1 Prophylaxis of Bladder Spasm

Oxybutynin 2.5mg tablets

The tablet formulation should be prescribed. Tablets can be crushed and dissolved and instructions on administration will be labelled by pharmacy. Liquid preparation should only be used in patients with a dose of less than 1.25mg.

The prescriber must check the patient’s weight is appropriate for age before prescribing.

Age

Dose

< 2 years

0.2mg/kg three times daily (Maximum 1.25mg three times daily)

2 to 6 years

2.5mg three times daily

>7 years

5mg three times daily

1.2 Analgesia

Paracetamol 120mg/5mL oral suspension (if > 6 years 250mg/5ml oral suspension)

For first 48 hours paracetamol should be given regularly, after which time ‘when required’ paracetamol should be prescribed.

Ibuprofen 100mg/5mL oral suspension

If appropriate and required, prescribe ‘when required’ for all patients.

1.3 Constipation

Lactulose solution

If patient has history a of constipation or is suffering with symptoms of constipation lactulose should be prescribed when required.

Age

Dose

<1 year

2.5mL twice daily

1 - 5 years

5mL twice daily

5 - 10 years   

10mL twice daily

Adjust dose according to response.

1.5 Saline Flush

Staged repairs may also require the use of Normal Saline 0.9% for twice daily flushing of the catheter. Prescribe if appropriate for patient.

2. Hypospadias Repair with no stent Pharmaceutical Care Pathway

Duration of treatment 5 - 7 days.

2.1 Prophylaxis of bladder spasm

Without the use of a catheter oxybutynin is not required.

2.2 Analgesia

Paracetamol and Ibuprofen should be prescribed if required as above in section 1.2.

2.3 Constipation

If required lactulose should be prescribed as above in section 1.3.

Editorial Information

Last reviewed: 12/05/2025

Next review date: 31/05/2028

Author(s): Boma Lee, Shahad Abbas.

Version: 5

Author email(s): boma.lee2@nhs.scot.

Approved By: Paediatric Urology Department

Document Id: 232

Evidence method

This guideline has been written in consultation with the medical literature and expertise in this field. This guideline incorporated consultation with surgical urology consultants, two clinical pharmacist and the urology nurse within The Royal Hospital for Children Glasgow, taking into account current practice and practice at other paediatric centres.