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Eradication of Pseudomonas Aeruginosa in Children with Cystic Fibrosis

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Background

Pseudomonas aeruginosa is recognized as being a significant respiratory pathogen for patients who have Cystic Fibrosis (CF). Chronic colonisation with Pseudomonas aeruginosa is associated with poorer clinical outcome and attempted eradication on first culture is aimed at preventing this. 1

Recommendation: When P. aeruginosa grows from respiratory culture for the first time (or when the patient has been clear of the organism for 6 months or more) eradication should be attempted 2

Guidance

MANAGEMENT OF A NEW CULTURE OF PSEUDOMONAS AERUGINOSA- GENERAL

SEGREGATION STATUS AND SECOND-LINE ANTIBIOTIC

EVALUATION PLAN

ANNUAL AUDIT OF :

  • NEW AND RECURRENT PSEUDOMONAS RATES
  • PSEUDOMONAS SUCCESSFUL ERADICATION RATES
References
  1. Frederiksen B, Koch C, Hoiby N. Antibiotic treatment of initial colonisation with Pseudomonas aeruginosa postpones chronic infection and prevents deterioration of pulmonary function cystic fibrosis. Pediatr Pulmonol 1997; 23:330- 335.
  2. Pseudomonas aeruginosa infection in people with cystic fibrosis. Suggestions for Prevention and Infection Control. CF Trust 2004 (updated Nov 2016)
  3. Brompton CF Guidelines 2017
  4. N. Høiby , B. Frederiksen T. Pressler. Eradication of early Pseudomonas aeruginosa infection. Department of Clinical Microbiology 9301, Rigshospitalet, University of Copenhagen, Juliane Maries Vej 22, 2100 Copenhagen, Denmark. Danish Cystic Fibrosis Center, Rigshospitalet, Copenhagen, Denmark
  5. EPIC Study 2012 
  6. BNFC- Drug information
Editorial Information

Last reviewed: 01 November 2019

Next review: 01 October 2021

Author(s): DR JANE WILKINSON; DR CHRISTINE PETERS; DR ROSIE HAGUE; MR STEVE BOWHAY

Version: 1

Approved By: Paediatric Drugs & Therapeutics Committee